Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate

Base Information

Chemical Name:Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate
CAS No.:263719-77-3
Molecular Formula:C₈H₁₆N₂O₄S
Molecular Weight:236.292
Hs Code.:
DSSTox Substance ID:DTXSID101123698
Nikkaji Number:J1.259.467D

Synonyms:263719-77-3;SCHEMBL22574311;DTXSID101123698;1,2,5-Thiadiazolidine-2-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester, 1,1-dioxide

Suppliers and Price of Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:236.08307817
Heavy Atom Count:15
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(S1(=O)=O)C

Technology Process of Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate

There total 4 articles about Tert-butyl 5-methyl-1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 263719-70-6
N¹-BOC,N³-methyl,N³-(2-chloroethyl) sulfamide

: 263719-77-3
tert-butyl 5-methyl-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 8h;
DOI:10.1016/S0040-4020(99)01025-X

Reference yield: 90.0%

: 263719-65-9
tert-butyl {[(2-hydroxyethyl)(methyl)amino]sulfonyl}carbamate

: 263719-77-3
tert-butyl 5-methyl-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; for 0.333333h;
DOI:10.1016/S0040-4020(99)01025-X

Reference yield:

: 147000-89-3
N-tert-butyloxycarbonylsulfamoyl chloride

: 263719-77-3
tert-butyl 5-methyl-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Et₃N / CH₂Cl₂ / 5 - 20 °C

2: 87 percent / NaBH₄ / tetrahydrofuran; H₂O / 0 - 20 °C

3: 90 percent / PPh₃; DIAD / CH₂Cl₂ / 0.33 h

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1: sulfamoylation / 2: Reduction / 3: Cyclization;
DOI:10.1016/S0040-4020(99)01025-X