(1R,2R)-trans-2-azidocyclopentanol

Base Information

• Chemical Name: (1R,2R)-trans-2-azidocyclopentanol
• CAS No.: 110716-79-5
• Molecular Formula: C₅H₉N₃O
• Molecular Weight: 127.146
• Mol file: 110716-79-5.mol

Synonyms:

Chemical Property of (1R,2R)-trans-2-azidocyclopentanol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-trans-2-azidocyclopentanol

There total 7 articles about (1R,2R)-trans-2-azidocyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R,2R)-trans-2-azidocyclopentyl acetate (260065-68-7) → (1R,2R)-trans-2-azidocyclopentanol (110716-79-5,88807-02-7)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm400529f

Reference yield: 95.0%

(1R,2R)-1-Azido-2-(trimethylsiloxy)cyclopentane → (1R,2R)-trans-2-azidocyclopentanol (110716-79-5,88807-02-7)

Guidance literature:

With hydrogenchloride; In methanol; water; for 4h; Reflux;

DOI:10.1039/c1cc00024a

Reference yield: 40.0%

(+/-)-trans-2-azido-cyclopentyl butyrate → (1S,2S)-2-azido-cyclopentyl butyrate (756874-86-9) + (1R,2R)-trans-2-azidocyclopentanol (110716-79-5,88807-02-7)

Guidance literature:

With Pseudomonas cepacia lipase (Amano-PS); In phosphate buffer; for 1.5h; pH=7.2; Enzymatic reaction;

DOI:10.1021/jo049442+

upstream raw materials:

Cyclopentene oxide

(1R,2R)-trans-2-azidocyclopentyl acetate

(±)-trans-2-azidocyclopentanol

Downstream raw materials:

C₁₇H₁₉NO₃S₂

(1R,2R)-trans-2-(4-phenoxybenzenesulfonamido)cyclopentyl thiobenzoate

(1S,2R)-cis-2-(4-phenoxybenzenesulfonamido)cyclopentanol

(1S,2R)-cis-2-azidocyclopentanol