Technology Process of acetyl-5-deoxy-5-(cyclohexyl)(carbamoyl)methyl-2,3-O-diacetyl-β-D-ribofuranoside
There total 8 articles about acetyl-5-deoxy-5-(cyclohexyl)(carbamoyl)methyl-2,3-O-diacetyl-β-D-ribofuranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid
2.1: pyridine; iodine; triphenylphosphine / 1,4-dioxane
3.1: sodium hydride / dimethyl sulfoxide
4.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere
4.2: 3 h / 20 °C / Inert atmosphere
5.1: palladium 10% on activated carbon; hydrogen / methanol / 30 °C
6.1: dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide; methanol / 1 h / Reflux
7.1: sulfuric acid / water; 1,4-dioxane / Reflux
8.1: pyridine / 20 °C
With
pyridine; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; iodine; sodium hydride; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;
DOI:10.1021/ml4002503
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine; iodine; triphenylphosphine / 1,4-dioxane
2.1: sodium hydride / dimethyl sulfoxide
3.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere
3.2: 3 h / 20 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol / 30 °C
5.1: dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide; methanol / 1 h / Reflux
6.1: sulfuric acid / water; 1,4-dioxane / Reflux
7.1: pyridine / 20 °C
With
pyridine; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; iodine; sodium hydride; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;
DOI:10.1021/ml4002503
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol / 30 °C
3.1: dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide; methanol / 1 h / Reflux
4.1: sulfuric acid / water; 1,4-dioxane / Reflux
5.1: pyridine / 20 °C
With
pyridine; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;
DOI:10.1021/ml4002503
