2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

Base Information

Chemical Name:2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran
CAS No.:93489-89-5
Molecular Formula:C₄₁H₆₀O₆S
Molecular Weight:680.99
Hs Code.:

2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

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Chemical Property of 2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

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Technology Process of 2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

There total 2 articles about 2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 80320-89-4
(R)-4-(2-Benzenesulfonyl-ethyl)-2,2,4-trimethyl-[1,3]dioxolane

: 82268-14-2
2-[(3S,9S,10R,13R,14R)-17-((S)-2-Bromo-1-methyl-ethyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-tetrahydro-pyran

: 93489-89-5,100019-15-6,100019-16-7
2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -20 ℃;
DOI:10.1016/S0040-4039(01)91020-2

Reference yield:

: 6236-10-8,2306-22-1
(R)-(-)-citramalic acid

: 93489-89-5,100019-15-6,100019-16-7
2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 2 steps

2: 95 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -20 °C

In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(01)91020-2

Reference yield:

: 93489-89-5,100019-15-6,100019-16-7
2-{(3S,9S,10R,13R,14R)-17-[(R)-3-Benzenesulfonyl-1-methyl-4-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-butyl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy}-tetrahydro-pyran

: 93489-95-3
25R,26-dihydroxy-23-oxovitamin D₃

Guidance literature:: Multi-step reaction with 4 steps

2: 54 percent / O₂, LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -20 °C

3: 60 percent / KF, 18-crown-6 / dimethylformamide / Ambient temperature

4: 1.) irradiation, 2.) thermal isomerization

With potassium fluoride; 18-crown-6 ether; oxygen; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)91020-2