Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]-

Base Information

• Chemical Name: Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]-
• CAS No.: 105602-16-2
• Molecular Formula: C14H21NO2
• Molecular Weight: 235.326
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50357753
• Wikidata: Q82137820
• Mol file: 105602-16-2.mol

Synonyms:105602-16-2;Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]-;1-[2-(2-methoxyphenoxy)ethyl]piperidine;1-[2-(2-methoxyphenoxy)ethyl]-piperidine;HMS1556O02;TimTec1_008054;Oprea1_397448;DTXSID50357753;AKOS000506834;IDI1_033708;UPCMLD0ENAT5806606:001

Chemical Property of Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]-

Chemical Property:

• PSA: 21.70000
• LogP: 2.49780
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 235.157228913
• Heavy Atom Count: 17
• Complexity: 204

Purity/Quality:

99% ^*data from raw suppliers

1-[2-(2-METHOXYPHENOXY)ETHYL]-PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCCN2CCCCC2

Technology Process of Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]-

There total 3 articles about Piperidine, 1-[2-(2-methoxyphenoxy)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-chloroethylpiperidine hydrochloride (2008-75-5) + 2-methoxy-phenol (90-05-1) → 1-(2-(2-methoxyphenoxy)ethyl)piperidine (105602-16-2)

Guidance literature:

2-methoxy-phenol; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h;

N-chloroethylpiperidine hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1016/j.tet.2021.132108

Reference yield: 60.0%

piperidine (110-89-4) + 2-(methoxyphenoxy)ethylbromide (4463-59-6) → 1-(2-(2-methoxyphenoxy)ethyl)piperidine (105602-16-2)

Guidance literature:

With sodium carbonate; In ethanol; for 20h; Heating;

Reference yield:

2-methoxy-phenol (90-05-1) → 1-(2-(2-methoxyphenoxy)ethyl)piperidine (105602-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydroxide / methanol / 15 h / Heating

2: 60 percent / Na₂CO₃ / ethanol / 20 h / Heating

With sodium hydroxide; sodium carbonate; In methanol; ethanol;

upstream raw materials:

piperidine

2-(methoxyphenoxy)ethylbromide

2-methoxy-phenol

N-chloroethylpiperidine hydrochloride

Downstream raw materials:

2-methoxy-phenol

Refernces

• 1、 Strappaghetti,Brasili. "Synthesis and pharmacological evaluation of cyclic and opened thioanalogues of piperoxan". . p. 794 - 800. Retrieved 2007/10/02.