(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

Base Information

Chemical Name:(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate
CAS No.:1255860-37-7
Molecular Formula:C₂₈H₃₂N₃O₁₀P
Molecular Weight:601.55
Hs Code.:

(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

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Chemical Property of (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

Chemical Property:

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Technology Process of (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

There total 10 articles about (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₂N₂O₇

: 1255860-37-7
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; sodium methylate

2: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

4: pyridine / 2 h

5: sodium hydride / tetrahydrofuran / 2 h / 20 °C

6: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

7: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen; sodium methylate; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm4015422

Reference yield:

: 1255860-30-0
1-((2R,3R,4R,5R)-3-allyl-4-(benzyloxy)-5-(benzyloxymethyl)-3-hydroxytetra-hydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1255860-37-7
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

3: pyridine / 2 h

4: sodium hydride / tetrahydrofuran / 2 h / 20 °C

5: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

6: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm4015422

Reference yield:

: 1255860-31-1
1-[(2R,3R,4R,5R)-4-(benzyloxy)-5-(benzyloxy-methyl)-3-hydroxy-3-(2-hydroxyethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

: 1255860-37-7
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 2 h

2: sodium hydride / tetrahydrofuran / 2 h / 20 °C

3: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

4: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; hydrogen; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm4015422