6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1354829-61-0
Molecular Formula:C₁₉H₂₂N₂O₄
Molecular Weight:342.395
Hs Code.:

Synonyms:

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Chemical Property of 6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4230-93-7
1,2-dimethoxy-4-(2-nitro-vinyl)-benzene

: 1354829-61-0
6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

1.2: Cooling with ice

2.1: formic acid / 0.17 h / 0 °C

2.2: 24 h / 0 - 50 °C

3.1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

4.1: oxygen; vanadia / 24 h / 60 °C / 760.05 Torr / Neat (no solvent)

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; oxygen; vanadia; In tetrahydrofuran; ethylene glycol; isopropyl alcohol; 4.1: Henry reaction;
DOI:10.1039/c1ob06466e

Reference yield:

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1354829-61-0
6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

2: oxygen; vanadia / 24 h / 60 °C / 760.05 Torr / Neat (no solvent)

With potassium phosphate; copper(l) iodide; oxygen; vanadia; In ethylene glycol; isopropyl alcohol; 2: Henry reaction;
DOI:10.1039/c1ob06466e

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1354829-61-0
6,7-dimethoxy-1-(1-nitroethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; acetic acid / 1.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.2: Cooling with ice

3.1: formic acid / 0.17 h / 0 °C

3.2: 24 h / 0 - 50 °C

4.1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

5.1: oxygen; vanadia / 24 h / 60 °C / 760.05 Torr / Neat (no solvent)

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; ammonium acetate; oxygen; vanadia; acetic acid; In tetrahydrofuran; ethylene glycol; isopropyl alcohol; 1.1: Henry reaction / 5.1: Henry reaction;
DOI:10.1039/c1ob06466e