Technology Process of 5'-fluoro-5'-deoxy-2',3'-di-O-acetyl-1-(2,4-dinitrophenyl)inosine
There total 5 articles about 5'-fluoro-5'-deoxy-2',3'-di-O-acetyl-1-(2,4-dinitrophenyl)inosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 0 - 20 °C
2: pyridine / 1 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C
With
pyridine; potassium carbonate; trifluoroacetic acid;
In
N,N-dimethyl-formamide;
DOI:10.3390/molecules171113036
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / acetone / 2 h / 20 °C
2: tetrabutyl ammonium fluoride; p-toluenesulfonyl fluoride / tetrahydrofuran / 18 h / Reflux
3: sodium hydroxide / 1,4-dioxane / 4 h / 20 °C
4: trifluoroacetic acid / 0 - 20 °C
5: pyridine / 1 h / 20 °C
6: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C
With
pyridine; p-toluenesulfonyl fluoride; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone;
DOI:10.3390/molecules171113036
