N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

Base Information

Chemical Name:N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide
CAS No.:1369967-05-4
Molecular Formula:C₁₅H₁₆N₂OS
Molecular Weight:272.371
Hs Code.:

Synonyms:

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Chemical Property of N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

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Technology Process of N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

There total 5 articles about N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369966-95-9
N-(3-bromo-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

: 98-80-6
phenylboronic acid

: 1369967-05-4
N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 150 ℃; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm201537d

Reference yield:

: 1369967-31-6
2-acetamido-6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid

: 1369967-05-4
N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

2: bromine / chloroform / 1 h / -10 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 25 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl acetamide; 4: Suzuki coupling;
DOI:10.1021/jm201537d

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1369967-05-4
N-(3-phenyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: morpholine; sulfur / ethanol / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux

4: N,N-dimethyl acetamide / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

5: bromine / chloroform / 1 h / -10 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 25 °C / Inert atmosphere

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 150 °C / Inert atmosphere; Microwave irradiation

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; sulfur; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; 7: Suzuki coupling;
DOI:10.1021/jm201537d