20,25-dihydroxyvitamin D₃

Base Information

Chemical Name:20,25-dihydroxyvitamin D₃
CAS No.:1372617-13-4
Molecular Formula:C₂₇H₄₄O₃
Molecular Weight:416.645
Hs Code.:

Synonyms:

Suppliers and Price of 20,25-dihydroxyvitamin D₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 20,25-dihydroxyvitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 20,25-dihydroxyvitamin D₃

There total 17 articles about 20,25-dihydroxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-14-6
Calciferol

: 1372617-13-4
20,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 15 steps

1.1: potassium permanganate; water / ethanol / -20 - 20 °C / Inert atmosphere

2.1: dmap; 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: pyridine; lead(IV) acetate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

3.3: 1 h / 0 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

5.1: water; 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; iso-butanol / 24 h / 60 °C / Inert atmosphere

6.1: sodium periodate / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

7.1: toluene-4-sulfonic acid; morpholine / toluene / 1 h / 80 °C / Inert atmosphere

8.1: potassium permanganate; aluminum oxide / acetone / 2 h / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

10.1: dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

11.1: magnesium; iodine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

11.2: 0 - 20 °C / Inert atmosphere

12.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere; Molecular sieve

13.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

14.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

14.2: 3 h / -78 °C / Inert atmosphere

15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With morpholine; pyridine; 1H-imidazole; 2,6-dimethylpyridine; lead(IV) acetate; dmap; aluminum oxide; potassium permanganate; sodium periodate; osmium(VIII) oxide; n-butyllithium; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; water; iodine; toluene-4-sulfonic acid; magnesium; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; iso-butanol; 14.1: |Wittig-Horner Reaction / 14.2: |Wittig-Horner Reaction;
DOI:10.1016/j.bioorg.2022.105660

Reference yield:

: (1S,3aR,7aR)-1-[(S)-2′-hydroxy-6′-methyl-6′-[(triethylsilyl)oxy]heptan-2′-yl]-7a-methyloctahydro-4H-inden-4-one

: 1372617-13-4
20,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; 2.1: |Wittig-Horner Reaction / 2.2: |Wittig-Horner Reaction;
DOI:10.1016/j.bioorg.2022.105660

Reference yield:

: 96685-53-9
(2Z)-2-<(5S)-5-(tert-butyldimethylsilyloxy)-2-methylene-cyclohexylidene>-ethanol

: 1372617-13-4
20,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; water / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; water; 3.1: |Wittig-Horner Reaction / 3.2: |Wittig-Horner Reaction;
DOI:10.1016/j.bioorg.2022.105660