13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5,9,11⁽¹⁵⁾-hexaen-12-one

Base Information

• Chemical Name: 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5,9,11⁽¹⁵⁾-hexaen-12-one
• CAS No.: 1394236-95-3
• Molecular Formula: C₂₅H₁₉N₃O₄S
• Molecular Weight: 457.51
• Mol file: 1394236-95-3.mol

Synonyms:

Chemical Property of 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5,9,11⁽¹⁵⁾-hexaen-12-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5,9,11⁽¹⁵⁾-hexaen-12-one

There total 5 articles about 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5,9,11⁽¹⁵⁾-hexaen-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(furan-2-ylmethyl)-5-[(4-methylbenzene)sulfonyl]-N-(prop-2-yn-1-yl)-5H-[1,2,4]triazino[5,6-b]indole-3-carboxamide (1394238-00-6) → 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2(7),3,5,9,11(15)-hexaen-12-one (1394236-95-3)

Guidance literature:

In diethylene glycol dimethyl ether; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.3762/bjoc.8.93

Reference yield:

C12H10N4O2 (1394237-93-4) → 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2(7),3,5,9,11(15)-hexaen-12-one (1394236-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 7 h / 20 °C / Inert atmosphere

2.1: zirconium(IV) tert-butoxide / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: diethylene glycol dimethyl ether / 0.33 h / Inert atmosphere; Microwave irradiation

With zirconium(IV) tert-butoxide; triethylamine; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; 3.1: Inverse electron demand Diels-Alder reaction;

DOI:10.3762/bjoc.8.93

Reference yield:

furan-2-ylmethanamine (617-89-0) → 13-(furan-2-ylmethyl)-8-[(4-methylbenzene)sulfonyl]-8,10,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2(7),3,5,9,11(15)-hexaen-12-one (1394236-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; toluene / 4.5 h / 0 - 20 °C / Inert atmosphere

2: zirconium(IV) tert-butoxide / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: diethylene glycol dimethyl ether / 0.33 h / Inert atmosphere; Microwave irradiation

With zirconium(IV) tert-butoxide; triethylamine; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; toluene; 3: Inverse electron demand Diels-Alder reaction;

DOI:10.3762/bjoc.8.93

upstream raw materials:

N-(furan-2-ylmethyl)prop-2-yn-1-amine

ethyl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

N-(furan-2-ylmethyl)-5-[(4-methylbenzene)sulfonyl]-N-(prop-2-yn-1-yl)-5H-[1,2,4]triazino[5,6-b]indole-3-carboxamide

C₁₂H₁₀N₄O₂