methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Base Information

Chemical Name:methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam
CAS No.:864815-53-2
Molecular Formula:C₅₇H₆₃ClN₂O₁₄
Molecular Weight:1035.59
Hs Code.:

methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Synonyms:

Suppliers and Price of methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

There total 17 articles about methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (4R,5S,6S)-2-acetoxy-5-benzyloxy-3-chloro-6-methyl-tetrahydro-pyran-4-yl ester

: 864815-53-2
methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Guidance literature:: Multi-step reaction with 10 steps

1.1: 91 percent / 3 Angstroem molecular sieves; BF₃*OEt₂ / CH₂Cl₂ / 2 h

2.1: 3 Angstroem molecular sieves / CH₂Cl₂ / 1 h

2.2: 92 percent / NIS; AgOTf / CH₂Cl₂ / 0.25 h

3.1: 81 percent / NaOMe; MeOH / CH₂Cl₂ / 12 h / 20 °C

4.1: 86 percent / NIS; TfOH / CH₂Cl₂ / 2 h / -20 °C

5.1: aq. NH₂NH₂ / ethanol / 24 h / Heating

6.1: TBAF / tetrahydrofuran / 24 h

7.1: 0.510 g / TBTU; HOBt; N-ethylmorpholine / dimethylformamide / 2 h

8.1: TEMPO; KBr; aq. NaHCO₃ / NaOCl / acetonitrile / 1 h / pH 10.5

9.1: piperidine / dimethylformamide / 0.5 h

10.1: 0.22 g / PyBOP / dimethylformamide / 1 h

With piperidine; N-ethylmorpholine;; methanol; 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-iodo-succinimide; trifluorormethanesulfonic acid; 3 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; sodium hydrogencarbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; potassium bromide; sodium hypochlorite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b416106h

Reference yield:

: 864815-49-6
methyl (3-O-benzoyl-4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside

: 864815-53-2
methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / NaOMe; MeOH / CH₂Cl₂ / 12 h / 20 °C

2: 86 percent / NIS; TfOH / CH₂Cl₂ / 2 h / -20 °C

3: aq. NH₂NH₂ / ethanol / 24 h / Heating

4: TBAF / tetrahydrofuran / 24 h

5: 0.510 g / TBTU; HOBt; N-ethylmorpholine / dimethylformamide / 2 h

6: TEMPO; KBr; aq. NaHCO₃ / NaOCl / acetonitrile / 1 h / pH 10.5

7: piperidine / dimethylformamide / 0.5 h

8: 0.22 g / PyBOP / dimethylformamide / 1 h

With piperidine; N-ethylmorpholine;; methanol; 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-iodo-succinimide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; sodium hydrogencarbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; potassium bromide; sodium hypochlorite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b416106h

Reference yield:

: 864815-52-1
methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-4,6-O-benzylidene-2-deoxy-2-(N-fluorenylmethoxycarbonyl-β-alanyl)-amido-β-D-glucopyranoside

: 864815-53-2
methyl (2,3,4-tri-O-benzyl-α-L-mannopyranosyluronyl)-(1->3)-(4-O-benzyl-2-chloro-2-deoxy-α-L-rhamnopyranosyl)-(1->3)-2-(3-aminopropionamido)-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside lactam

Guidance literature:: Multi-step reaction with 3 steps

1: TEMPO; KBr; aq. NaHCO₃ / NaOCl / acetonitrile / 1 h / pH 10.5

2: piperidine / dimethylformamide / 0.5 h

3: 0.22 g / PyBOP / dimethylformamide / 1 h

With piperidine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; potassium bromide; sodium hypochlorite; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b416106h