{1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester
CAS No.:1026311-06-7
Molecular Formula:C₂₁H₁₆F₃N₃O₃
Molecular Weight:415.372
Hs Code.:

Synonyms:

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Chemical Property of {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

There total 11 articles about {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 1026311-06-7
{1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 91 percent / thionyl chloride / 1 h / Heating

2: NaH / dimethylformamide / 12 h / Ambient temperature

3: 1.) TFA / 1.) RT, 20 h, 2.) toluene, reflux, 2 h

4: 91 percent / diethyl ether; petroleum ether / Ambient temperature

5: 95 percent / acetic anhydride / dimethylsulfoxide / 2 h / Ambient temperature

6: 69 percent / dimethylsulfoxide / 0.5 h / 15 - 20 °C

7: 92 percent / TFA, anisole / 2 h / Ambient temperature

8: Et₃N / acetone / 1.5 h / -25 - -20 °C

9: NaN₃ / H₂O; acetone / 0.5 h / 5 °C

10: dioxane / 2 h / Heating

11: 92 percent / 1 N aq. NaOH / ethanol; dioxane / 2 h / Ambient temperature

12: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; thionyl chloride; sodium azide; acetic anhydride; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; Petroleum ether;
DOI:10.1248/cpb.42.2063

Reference yield:

: 122894-73-9
ethyl 2,3,4,5-tetrafluorobenzenecarboxylate

: 1026311-06-7
{1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: NaH / dimethylformamide / 12 h / Ambient temperature

2: 1.) TFA / 1.) RT, 20 h, 2.) toluene, reflux, 2 h

3: 91 percent / diethyl ether; petroleum ether / Ambient temperature

4: 95 percent / acetic anhydride / dimethylsulfoxide / 2 h / Ambient temperature

5: 69 percent / dimethylsulfoxide / 0.5 h / 15 - 20 °C

6: 92 percent / TFA, anisole / 2 h / Ambient temperature

7: Et₃N / acetone / 1.5 h / -25 - -20 °C

8: NaN₃ / H₂O; acetone / 0.5 h / 5 °C

9: dioxane / 2 h / Heating

10: 92 percent / 1 N aq. NaOH / ethanol; dioxane / 2 h / Ambient temperature

11: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; sodium azide; acetic anhydride; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; Petroleum ether;
DOI:10.1248/cpb.42.2063

Reference yield:

: 123161-38-6
ethyl 4-carboxymethyl-2,3,5-trifluorobenzoate

: 1026311-06-7
{1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / diethyl ether; petroleum ether / Ambient temperature

2: 95 percent / acetic anhydride / dimethylsulfoxide / 2 h / Ambient temperature

3: 69 percent / dimethylsulfoxide / 0.5 h / 15 - 20 °C

4: 92 percent / TFA, anisole / 2 h / Ambient temperature

5: Et₃N / acetone / 1.5 h / -25 - -20 °C

6: NaN₃ / H₂O; acetone / 0.5 h / 5 °C

7: dioxane / 2 h / Heating

8: 92 percent / 1 N aq. NaOH / ethanol; dioxane / 2 h / Ambient temperature

9: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; sodium azide; acetic anhydride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; dimethyl sulfoxide; acetone; Petroleum ether;
DOI:10.1248/cpb.42.2063