3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline

Base Information

• Chemical Name: 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline
• CAS No.: 111221-11-5
• Molecular Formula: C₃₆H₄₀N₂O₂
• Molecular Weight: 532.726
• Mol file: 111221-11-5.mol

Synonyms:

Chemical Property of 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline

There total 9 articles about 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-dinitrobenzene (99-65-0) → 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline (111221-11-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 11.4 g / copper(I) t-butoxide/pyridine / 1,2-dimethoxy-ethane / 21 h / 80 °C

2: 6 g / ferric chloride / trichloroethene

3: 10.6 g / hexamethylphosphoric acid triamide / 20 h

4: 5.9 g / iodine/periodic acid dihydrate / H₂O; acetic acid; H₂SO₄ / 24 h / 75 °C

5: 3.8 g / copper(II)trifluoromethanesulphonate/copper powder, aq NH₃ / acetone; acetonitrile; dimethylsulfoxide / 1.) 0 deg C, 4 h; 2.) 5 deg C, 18 h

6: 7.3 g / zinc-copper couple / H₂O; acetic acid / 4 h / 115 °C

7: 1.) hydrochloric acid/sodium nitrite, 2.) urea, mercuric iodide/potassium iodide / 1.) dimethylformamide/water, -1 deg C, 3.5 h; 2.) dimethylformamide/water, 0 to 5 deg C, 3 h, dimethylsulfoxide, 125 deg C, 24 h

With pyridine; hydrogenchloride; ammonium hydroxide; zinc copper; iodine; copper (I) tert-butoxide; copper(II) bis(trifluoromethanesulfonate); copper; periodic acid; urea; potassium iodide; mercury(II) iodide; sodium nitrite; iron(III) chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; Trichloroethylene; sulfuric acid; water; acetic acid; dimethyl sulfoxide; acetone; acetonitrile;

Reference yield:

3-Iodotoluene (625-95-6) → 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline (111221-11-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 11.4 g / copper(I) t-butoxide/pyridine / 1,2-dimethoxy-ethane / 21 h / 80 °C

2: 6 g / ferric chloride / trichloroethene

3: 10.6 g / hexamethylphosphoric acid triamide / 20 h

4: 5.9 g / iodine/periodic acid dihydrate / H₂O; acetic acid; H₂SO₄ / 24 h / 75 °C

5: 3.8 g / copper(II)trifluoromethanesulphonate/copper powder, aq NH₃ / acetone; acetonitrile; dimethylsulfoxide / 1.) 0 deg C, 4 h; 2.) 5 deg C, 18 h

6: 7.3 g / zinc-copper couple / H₂O; acetic acid / 4 h / 115 °C

7: 1.) hydrochloric acid/sodium nitrite, 2.) urea, mercuric iodide/potassium iodide / 1.) dimethylformamide/water, -1 deg C, 3.5 h; 2.) dimethylformamide/water, 0 to 5 deg C, 3 h, dimethylsulfoxide, 125 deg C, 24 h

With pyridine; hydrogenchloride; ammonium hydroxide; zinc copper; iodine; copper (I) tert-butoxide; copper(II) bis(trifluoromethanesulfonate); copper; periodic acid; urea; potassium iodide; mercury(II) iodide; sodium nitrite; iron(III) chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; Trichloroethylene; sulfuric acid; water; acetic acid; dimethyl sulfoxide; acetone; acetonitrile;

Reference yield:

1-(tert-butyl)-3-iodo-5-methylbenzene (111220-30-5) → 3,8-dimethoxy-4,7-bis-(5-t-butyl-3-methylphenyl)benzocinnoline (111221-11-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 22.7 g / copper(I) t-butoxide/pyridine / 1,2-dimethoxy-ethane / 17 h / 75 °C

2: 10.6 g / hexamethylphosphoric acid triamide / 20 h

3: 5.9 g / iodine/periodic acid dihydrate / H₂O; acetic acid; H₂SO₄ / 24 h / 75 °C

4: 3.8 g / copper(II)trifluoromethanesulphonate/copper powder, aq NH₃ / acetone; acetonitrile; dimethylsulfoxide / 1.) 0 deg C, 4 h; 2.) 5 deg C, 18 h

5: 7.3 g / zinc-copper couple / H₂O; acetic acid / 4 h / 115 °C

6: 1.) hydrochloric acid/sodium nitrite, 2.) urea, mercuric iodide/potassium iodide / 1.) dimethylformamide/water, -1 deg C, 3.5 h; 2.) dimethylformamide/water, 0 to 5 deg C, 3 h, dimethylsulfoxide, 125 deg C, 24 h

With hydrogenchloride; ammonium hydroxide; zinc copper; iodine; copper(II) bis(trifluoromethanesulfonate); copper; periodic acid; urea; potassium iodide; mercury(II) iodide; sodium nitrite; pyridine; copper (I) tert-butoxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; sulfuric acid; water; acetic acid; dimethyl sulfoxide; acetone; acetonitrile;

upstream raw materials:

4'',6'-dimethoxy-3,3'''-dimethyl-5,5'''-di-t-butyl-m-quaterphenyl-2',2''-diamine

meta-dinitrobenzene

3-Iodotoluene

1-(tert-butyl)-3-iodo-5-methylbenzene