(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

Base Information

Chemical Name:(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate
CAS No.:1350765-94-4
Molecular Formula:C₃₁H₅₀N₇O₁₀P
Molecular Weight:711.753
Hs Code.:

(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

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Technology Process of (2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

There total 3 articles about (2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.6%

: 1350765-94-4
(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:

Reference yield:

: 41324-79-2
(S)-methyl-2-amino cyclohexyl acetate hydrochloride

: C₁₃H₁₈Cl₂N₅O₆P

: 1350765-94-4
(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; Inert atmosphere;
DOI:10.1021/jm2011673

Reference yield:

: 1106011-12-4
(2R,3R,4R,5R)-2-(2-amino-6-ethoxy-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol

: 1350765-94-4
(2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / -78 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2011673