2H-Pyran-2-carboxylic acid, tetrahydro-5-(1-methylethyl)-4-phenyl-

Base Information

• Chemical Name: 2H-Pyran-2-carboxylic acid, tetrahydro-5-(1-methylethyl)-4-phenyl-
• CAS No.: 105615-59-6
• Molecular Formula: C15H20O3
• Molecular Weight: 248.322
• Mol file: 105615-59-6.mol

Synonyms:

Chemical Property of 2H-Pyran-2-carboxylic acid, tetrahydro-5-(1-methylethyl)-4-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyran-2-carboxylic acid, tetrahydro-5-(1-methylethyl)-4-phenyl-

There total 4 articles about 2H-Pyran-2-carboxylic acid, tetrahydro-5-(1-methylethyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(5-Isopropyl-4-phenyl-4H-pyran)-carbonsaeure (105507-79-7) → 5-Isopropyl-4-phenyl-3,4,5,6-tetrahydro-2H-2-pyrancarbonsaeure (105615-59-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 50 ℃; for 16h; under 2206.5 Torr;

DOI:10.1002/ardp.19863190806

Reference yield:

(E)-1-(3-methylbut-1-en-1-yl)piperidine (57422-87-4) → 5-Isopropyl-4-phenyl-3,4,5,6-tetrahydro-2H-2-pyrancarbonsaeure (105615-59-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / methanol / 2.5 h / 0 °C

2: 56 percent / 2N aq. HCl / dioxane / 15 h / Heating

3: 75 percent / p-toluenesulfonic acid / toluene / 26 h / Heating

4: 95 percent / H₂ / 10 percent Pd/C / ethyl acetate / 16 h / 50 °C / 2206.5 Torr

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; toluene;

DOI:10.1002/ardp.19863190806

Reference yield:

methyl benzylidenepyruvate (107969-78-8) → 5-Isopropyl-4-phenyl-3,4,5,6-tetrahydro-2H-2-pyrancarbonsaeure (105615-59-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / methanol / 2.5 h / 0 °C

2: 56 percent / 2N aq. HCl / dioxane / 15 h / Heating

3: 75 percent / p-toluenesulfonic acid / toluene / 26 h / Heating

4: 95 percent / H₂ / 10 percent Pd/C / ethyl acetate / 16 h / 50 °C / 2206.5 Torr

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; toluene;

DOI:10.1002/ardp.19863190806

upstream raw materials:

2-(5-Isopropyl-4-phenyl-4H-pyran)-carbonsaeure

(E)-1-(3-methylbut-1-en-1-yl)piperidine

methyl benzylidenepyruvate

2-(5,6-Dihydro-5-isopropyl-4-phenyl-6-piperidino-4H-pyran)-carbonsaeuremethylester

Refernces