(1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

Base Information

Chemical Name:(1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile
CAS No.:309254-82-8
Molecular Formula:C₂₅H₂₉N₃
Molecular Weight:371.525
Hs Code.:

Synonyms:

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Chemical Property of (1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

Chemical Property:

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Technology Process of (1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

There total 6 articles about (1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 309254-70-4
β-(3,4-Dihydro-1-naphthyl)propionic acid

: 309254-82-8
(1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: H₂; Et₃N / Ru(OAc)2; (R)-(6,6'-dimethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) / methanol / 20 °C / 75006 Torr

2: trifluoroacetic anhydride / trifluoroacetic acid / 20 °C

3: NH₂OH*HCl; NaOAc / H₂O; methanol; tetrahydrofuran / 70 °C

4: NH₃; H₂ / Raney Ni / methanol / 20 °C

5: K₂CO₃ / ethanol; H₂O / Heating

6: acetic acid / 20 °C

With hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; triethylamine; trifluoroacetic anhydride; ruthenium bis(acetate); nickel; (R)-(6,6′-dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine); In tetrahydrofuran; methanol; ethanol; water; acetic acid; trifluoroacetic acid; 1: Hydrogenation / 2: cyclocondensation / 3: Condensation / 4: Hydrogenation / 5: Hofmann elimination; Michael addition / 6: Strecker reaction;
DOI:10.1016/S0223-5234(00)00171-9

Reference yield:

: 309254-81-7
(R)-2,3,3a,4,5,6-hexahydro-phenalen-1-one

: 309254-82-8
(1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH*HCl; NaOAc / H₂O; methanol; tetrahydrofuran / 70 °C

2: NH₃; H₂ / Raney Ni / methanol / 20 °C

3: K₂CO₃ / ethanol; H₂O / Heating

4: acetic acid / 20 °C

With hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; nickel; In tetrahydrofuran; methanol; ethanol; water; acetic acid; 1: Condensation / 2: Hydrogenation / 3: Hofmann elimination; Michael addition / 4: Strecker reaction;
DOI:10.1016/S0223-5234(00)00171-9

Reference yield:

: 309254-80-6
(R)-3-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid

: 309254-82-8
(1R,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic anhydride / trifluoroacetic acid / 20 °C

2: NH₂OH*HCl; NaOAc / H₂O; methanol; tetrahydrofuran / 70 °C

3: NH₃; H₂ / Raney Ni / methanol / 20 °C

4: K₂CO₃ / ethanol; H₂O / Heating

5: acetic acid / 20 °C

With hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; trifluoroacetic anhydride; nickel; In tetrahydrofuran; methanol; ethanol; water; acetic acid; trifluoroacetic acid; 1: cyclocondensation / 2: Condensation / 3: Hydrogenation / 4: Hofmann elimination; Michael addition / 5: Strecker reaction;
DOI:10.1016/S0223-5234(00)00171-9