3-(1,1-difluoroallyl)quinoxalin-2-ol

Base Information

Chemical Name:3-(1,1-difluoroallyl)quinoxalin-2-ol
CAS No.:1294512-27-8
Molecular Formula:C₁₁H₈F₂N₂O
Molecular Weight:222.194
Hs Code.:
Mol file:1294512-27-8.mol

Synonyms:

Suppliers and Price of 3-(1,1-difluoroallyl)quinoxalin-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(1,1-Difluoro-2-propen-1-yl)-2(1H)-quinoxalinone
10mg
$ 1320.00

Total 12 raw suppliers

Chemical Property of 3-(1,1-difluoroallyl)quinoxalin-2-ol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(1,1-Difluoro-2-propen-1-yl)-2(1H)-quinoxalinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-(1,1-Difluoro-2-propen-1-yl)-2(1H)-quinoxalinone is an antiviral agent and a Glecaprevir (1365970-03-1) intermediate.

Technology Process of 3-(1,1-difluoroallyl)quinoxalin-2-ol

There total 2 articles about 3-(1,1-difluoroallyl)quinoxalin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1294512-26-7
ethyl 3,3-difluoro-2-oxopent-4-enoate

: 95-54-5
1,2-diamino-benzene

: 1294512-27-8
3-(1,1-difluoroallyl)quinoxalin-2-ol

Guidance literature:: In ethanol; at 80 ℃; for 2h;

Reference yield:

: 1365970-40-6
C₇H₁₀F₂O₃

: 1294512-27-8
3-(1,1-difluoroallyl)quinoxalin-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 5 h / 20 °C

2: ethanol / 14 h / Reflux

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In ethanol; dichloromethane;

Reference yield:

: 1294512-27-8
3-(1,1-difluoroallyl)quinoxalin-2-ol

: C₃₀H₃₆F₂N₄O₇

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 65 °C

2.1: sodium t-butanolate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 4 h / 0 - 20 °C

3.1: dichloromethane; methanol; hexane / 0.5 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h

6.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride / toluene / 37 h / 110 °C / Inert atmosphere

With hydrogenchloride; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;