Technology Process of (6-Phenyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetic acid
There total 7 articles about (6-Phenyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) 1,3-dicyclohexylcarbodiimide (DCC), 2.) 1-hydroxybenzotriazole hydrate (HOBT) / CH2Cl2
2: ammonium acetate / ethanol / 3.5 h / Heating
3: COCl2 / toluene; tetrahydrofuran / 4 h / Heating
4: H2N-NH2*H2O / dimethylsulfoxide / 2 h / Heating
5: ethyl acetate / 1 h / 0 °C
6: p-toluenesulfonic acid monohydrate (PTSA) / toluene / 2.5 h / Heating
7: 2 M aq. NaOH / ethanol / 1 h
With
ammonium acetate; sodium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm00171a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2N-NH2*H2O / dimethylsulfoxide / 2 h / Heating
2: ethyl acetate / 1 h / 0 °C
3: p-toluenesulfonic acid monohydrate (PTSA) / toluene / 2.5 h / Heating
4: 2 M aq. NaOH / ethanol / 1 h
With
sodium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate;
In
ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm00171a005
![(6-Phenyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetic acid ethyl ester](/Databaselist/images/loading.webp)
