Doxorubicinol Citrate (Mixture of Diastereomers)

Base Information

• Chemical Name: Doxorubicinol Citrate (Mixture of Diastereomers)
• CAS No.: 1242592-26-2
• Molecular Formula: C₂₇H₃₁NO₁₁
• Molecular Weight: 545.543

Synonyms:

Chemical Property of Doxorubicinol Citrate (Mixture of Diastereomers)

Chemical Property:

• Melting Point: 195-201?C
• Storage Temp.: -20°C Freezer

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Doxorubicinol Citrate is a metabolite of Doxorubicinol (D194500), an anthracycline antibiotic related to the rhodomycins. Antineoplastic.

Technology Process of Doxorubicinol Citrate (Mixture of Diastereomers)

There total 1 articles about Doxorubicinol Citrate (Mixture of Diastereomers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ doxorubicinol (1242592-26-2,111955-90-9,276880-88-7,39004-85-8)

Guidance literature:

Adriamycin, NaCNBH3;

DOI:10.1021/jm00187a010

Reference yield:

doxorubicinol (1242592-26-2,111955-90-9,276880-88-7,39004-85-8) → C40H42O9Si

Guidance literature:

Multi-step reaction with 3 steps

1: 0.2N aq. HCl / 1 h / 80 °C

2: imidazole / dimethylformamide / 16 h / Ambient temperature

3: p-TsOH / dioxane / 1 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; toluene-4-sulfonic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

doxorubicinol (1242592-26-2,111955-90-9,276880-88-7,39004-85-8) → (8S,10S)-8-[2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 0.2N aq. HCl / 1 h / 80 °C

2: imidazole / dimethylformamide / 16 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; In N,N-dimethyl-formamide;

Downstream raw materials:

13-dihydroadriamycinone

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