(S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 116612-00-1
• Molecular Formula: C₃₁H₃₄Cl₃N₃O₆S
• Molecular Weight: 683.052
• Mol file: 116612-00-1.mol

Synonyms:

Chemical Property of (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 10 articles about (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(1S,3S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester (111468-02-1) → (S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,9-dihydro-1H-β-carboline-3-carboxylic acid methyl ester (111427-87-3) + (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester (116612-00-1)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85828-2

Reference yield: 10.0%

(1S,3S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester (111468-02-1) → (S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,9-dihydro-1H-β-carboline-3-carboxylic acid methyl ester (111427-87-3) + (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester (116612-00-1) + 1-(2-methyl-2-phenylthiopropyl)-3-methoxycarbonyl-β-carboline (111427-85-1,111427-86-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85828-2

Reference yield:

L-tryptophan methyl ester (4299-70-1) → (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester (116612-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) Lawesson's reagent

2: 1.) MeI; 2.) NaBH₄

3: 99 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

4: 10 percent / DDQ / CH₂Cl₂ / 0.5 h / Ambient temperature

With Lawessons reagent; sodium tetrahydroborate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; methyl iodide; In dichloromethane;

DOI:10.1016/S0040-4020(01)85828-2

upstream raw materials:

(1S,3S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

3-methyl-3-phenylsulfanyl-butanoic acid

<<(2,2,2-trichloroethyl)oxy>carbonyl>-L-proline

3-methyl-3-(phenylthio)butanal