Technology Process of Acetic acid 5-(3-methoxycarbonylamino-propyl)-2-oxo-4-phenyl-2,5-dihydro-furan-3-yl ester
There total 10 articles about Acetic acid 5-(3-methoxycarbonylamino-propyl)-2-oxo-4-phenyl-2,5-dihydro-furan-3-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 99 percent / MCPBA / CH2Cl2 / Ambient temperature
2: EtONa / ethanol / Heating
3: 80 percent / aq. NaOH / Heating
4: 77 percent / Me2NH, AcONa / acetic acid / 100 °C
5: 42 percent / OsO4,NaIO4 / dioxane / Ambient temperature
6: 96 percent / H2 / Pd-black / ethanol
7: 92 percent / Et3N / tetrahydrofuran / 0 °C
8: 96 percent / CrO3, H2SO4 / acetone; H2O / 0 °C
9: 71 percent / K2CO3 / methanol; H2O / Ambient temperature
10: pyridine
11: Et3N / tetrahydrofuran
12: 1.) NaN3
With
pyridine; chromium(VI) oxide; sodium periodate; osmium(VIII) oxide; sodium azide; sulfuric acid; hydrogen; sodium ethanolate; sodium acetate; potassium carbonate; dimethyl amine; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; sodium hydroxide; ethanol; dichloromethane; water; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)84436-6
- Guidance literature:
-
Multi-step reaction with 11 steps
1: EtONa / ethanol / Heating
2: 80 percent / aq. NaOH / Heating
3: 77 percent / Me2NH, AcONa / acetic acid / 100 °C
4: 42 percent / OsO4,NaIO4 / dioxane / Ambient temperature
5: 96 percent / H2 / Pd-black / ethanol
6: 92 percent / Et3N / tetrahydrofuran / 0 °C
7: 96 percent / CrO3, H2SO4 / acetone; H2O / 0 °C
8: 71 percent / K2CO3 / methanol; H2O / Ambient temperature
9: pyridine
10: Et3N / tetrahydrofuran
11: 1.) NaN3
With
pyridine; chromium(VI) oxide; sodium periodate; osmium(VIII) oxide; sodium azide; sulfuric acid; hydrogen; sodium ethanolate; sodium acetate; potassium carbonate; dimethyl amine; triethylamine;
palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; sodium hydroxide; ethanol; water; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)84436-6
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 42 percent / OsO4,NaIO4 / dioxane / Ambient temperature
2: 96 percent / H2 / Pd-black / ethanol
3: 92 percent / Et3N / tetrahydrofuran / 0 °C
4: 96 percent / CrO3, H2SO4 / acetone; H2O / 0 °C
5: 71 percent / K2CO3 / methanol; H2O / Ambient temperature
6: pyridine
7: Et3N / tetrahydrofuran
8: 1.) NaN3
With
pyridine; chromium(VI) oxide; sodium periodate; osmium(VIII) oxide; sodium azide; sulfuric acid; hydrogen; potassium carbonate; triethylamine;
palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetone;
DOI:10.1016/S0040-4039(00)84436-6