S-(+)-Mexiletine

Base Information

• Chemical Name: S-(+)-Mexiletine
• CAS No.: 94991-72-7
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.262
• Hs Code.: 2922299090
• Mol file: 94991-72-7.mol

Synonyms:2-Propanamine,1-(2,6-dimethylphenoxy)-, (S)-; (+)-Mexiletine; (S)-Mexiletine;S-(+)-Mexiletine; d-Mexiletine

Chemical Property of S-(+)-Mexiletine

Chemical Property:

• Vapor Pressure: 0.00642mmHg at 25°C
• Boiling Point: 271.5°C at 760 mmHg
• Flash Point: 112.2°C
• PSA: 35.25000
• Density: 0.979g/cm³
• LogP: 2.72970
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

≥99% ^*data from raw suppliers

(S)-1-(2,6-Dimethylphenoxy)propan-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-(+)-Mexiletine

There total 37 articles about S-(+)-Mexiletine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

RS-mexiletine (31828-71-4) → (R)-mexiletine (31828-71-4,61079-93-4,94991-72-7,94991-73-8)

Guidance literature:

RS-mexiletine; With L-amino acid oxidase from Crotalus adamanteus; ω-transaminase from Chromobacterium violaceum DSM 30191; sodium pyruvate; at 30 ℃; for 24h; pH=7; Resolution of racemate; aq. phosphate buffer;

With glucose dehydrogenase; D-Alanine; D-glucose; ω-Transaminases ATA-117; C₂₁H₂₈N₇O₁₄P₂⁽¹⁺⁾; at 30 - 75 ℃; optical yield given as %ee; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/ol901834x

Reference yield: 87.0%

(R)-2-[(2,6-dimethylphenoxy)methyl]-1-[(R)-1-phenylethyl]aziridine (1093278-41-1) → (R)-mexiletine (31828-71-4,61079-93-4,94991-72-7,94991-73-8)

Guidance literature:

With 1% Pd/C; hydrogen; In methanol; for 12h;

DOI:10.1016/j.tet.2008.09.068

Reference yield: 86.0%

(-)-(R)-2-[2-(2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione (265994-88-5) → (R)-mexiletine (31828-71-4,61079-93-4,94991-72-7,94991-73-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1016/j.tetasy.2009.11.014

upstream raw materials:

(2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide

RS-mexiletine

(+)-(S)-2-[2-(2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione

ethyl acetate

Downstream raw materials:

tert-butyl (R)-1-(2,6-dimethylphenoxy)propan-2-ylcarbamate

(2,6-dimethylphenoxy)-2-propanone