4β-Hydroxy DHEA (available to WADA laboratories only)

Base Information

• Chemical Name: 4β-Hydroxy DHEA (available to WADA laboratories only)
• CAS No.: 63518-24-1
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 63518-24-1.mol

Synonyms:

Chemical Property of 4β-Hydroxy DHEA (available to WADA laboratories only)

Chemical Property:

• Melting Point: 198-200 °C
• Boiling Point: 451.9±45.0 °C(Predicted)
• PKA: 14.30±0.70(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3β,4β-Dihydroxyandrost-5-en-17-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-Hydroxy DHEA (available to WADA laboratories only)

There total 10 articles about 4β-Hydroxy DHEA (available to WADA laboratories only) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

dehydroepiandrosterone (53-43-0) → 3β,4β-dihydroxyandrost-5-en-17-one (63518-24-1)

Guidance literature:

With formic acid; selenium(IV) oxide; In 1,4-dioxane; at 40 ℃; for 72h;

DOI:10.1016/S0040-4020(99)00973-4

Reference yield:

4β-acetoxy-3β-hydroxyandrost-5-en-17-one (50633-63-1) → 3β,4β-dihydroxyandrost-5-en-17-one (63518-24-1)

Guidance literature:

DOI:10.1080/00480169.2002.36247

Reference yield:

dehydroepiandrosterone (53-43-0) → 3β,4β-dihydroxyandrost-5-en-17-one (63518-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂O / 19 h

2: 1.) Hg(O₂CCF₃)2, 2.) aq. NaHCO₃, Hg(O₂CCF₃)2 / 1.) CH₂Cl₂, 24 h, 2.) CH₂Cl₂

With mercury(II) trifluoroacetate; sodium hydrogencarbonate; In water;

DOI:10.1016/S0039-128X(98)00076-2

upstream raw materials:

4β-acetoxy-3β-hydroxyandrost-5-en-17-one

3β,4β-diacetoxyandrost-5-en-17-one

dehydroepiandrosterone

3β-formyl-oxy-5-androsten-17-one

Downstream raw materials:

3β-ethoxycarbonyloxy-4β-hydroxyandrost-5-en-17-one

4β-hydroxy-3β-p-tolylsulphonyloxyandrost-5-en-17-one