(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

Base Information

Chemical Name:(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester
CAS No.:87872-87-5
Molecular Formula:C₃₄H₃₄ClN₆O₉P
Molecular Weight:737.106
Hs Code.:

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

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Chemical Property of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

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Technology Process of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

There total 7 articles about (4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 102490-50-6
2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

: 82556-11-4
o-chlorophenyl phosphoro-p-anisidochloridate

: 88160-16-1,88160-17-2
C₄₇H₄₅Cl₂N₇O₁₂P₂

: 87872-87-5
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

Guidance literature:: In pyridine; for 5h; Ambient temperature;

Reference yield: 50.0%

: 102490-50-6
2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

: 82556-11-4
o-chlorophenyl phosphoro-p-anisidochloridate

: 87872-87-5
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

Guidance literature:: In pyridine; for 6h; Ambient temperature;
DOI:10.1248/cpb.31.1910

Reference yield:

: 4546-55-8
N-benzoyladenosine

: 87872-87-5
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-furan-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 1 h

2: p-toluenesulfonic acid / tetrahydrofuran / 2 h / Ambient temperature

3: 1M tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h / Ambient temperature

4: 50 percent / pyridine / 6 h / Ambient temperature

With 1H-imidazole; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1910