N-acetyl chloride of L-phenylalanine

Base Information

• Chemical Name: N-acetyl chloride of L-phenylalanine
• CAS No.: 16225-10-8
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.675
• Mol file: 16225-10-8.mol

Synonyms:

Chemical Property of N-acetyl chloride of L-phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl chloride of L-phenylalanine

There total 2 articles about N-acetyl chloride of L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetamido cinnamic acid (55065-02-6,64590-80-3,5469-45-4) → 2-Acetylamino-3-phenyl-propionyl chloride (16225-10-8,40557-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / H₂, ⁽¹⁺⁾ClO₄^(1-) / benzene; ethanol / 25 °C / 802.6 Torr

2: SOCl₂

With thionyl chloride; +(COD)(S,S)-DIOP>⁺ClO4^-; hydrogen; In ethanol; benzene;

Reference yield:

(+)-N-acetylphenylalanine (2018-61-3,2901-75-9,7782-51-6,10172-89-1) → 2-Acetylamino-3-phenyl-propionyl chloride (16225-10-8,40557-45-7)

Guidance literature:

With thionyl chloride;

Reference yield:

N-acetyl chloride of L-phenylalanine (16225-10-8,40557-45-7) → L-(4-phenyl-3-acetylamino-2-oxobutyl)methylphosphinic acid (120649-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) butyl lithium / 1.) butyl lithium, -78 deg C, 5 min 2.) 2 h, -78 deg C to RT

2: 92.8 percent / enzyme alkaline mesintericopeptidase / various solvent(s) / 6 h / pH = 8.0

3: 71.2 percent / aniline / xylene / Heating

4: 96.3 percent / phosphodiesterase I / various solvent(s) / 6 h / 37 °C / pH = 8.8

With n-butyllithium; aniline; enzyme alkaline mesintericopeptidase; phosphodiesterase I; In xylene;

DOI:10.1016/S0040-4020(01)89835-5

upstream raw materials:

(+)-N-acetylphenylalanine

N-acetamido cinnamic acid

Downstream raw materials:

Methyl ester of (+)-N-acetylphenylalanine

<5-phenyl-4-acetamino-3-oxo-2-(ethoxymethylphosphinyl)>-L-pentanoic acid ethyl ester

L-(4-phenyl-3-acetylamino-2-oxobutyl)methylphosphinic acid

5-phenyl-4-amino-3-oxo-2-methylphosphino-L-pentanoic acid