5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide

Base Information

• Chemical Name: 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide
• CAS No.: 105639-84-7
• Molecular Formula: C9H21Cl2N2O6PS2
• Molecular Weight: 419.287
• Mol file: 105639-84-7.mol

Synonyms:

Chemical Property of 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide

There total 2 articles about 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-Mosfosfamide (84210-72-0,88859-04-5) → aldophosphamide (35144-64-0) + aldophosphamide hydrate (88685-78-3) + cis-4-hydroxycyclophosphamide (61903-29-5,88852-77-1,40277-05-2,61903-30-8,88852-78-2) + trans-4-hydroxycyclophosphamide (61903-30-8,88852-78-2,40277-05-2,61903-29-5,88852-77-1) + C9H21Cl2N2O6PS2 (105639-84-7) + 2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ5-[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid (92745-18-1,88859-04-5)

Guidance literature:

With acetate bufer; In water; at 37 ℃; Rate constant; Mechanism; var. buffer conc., var. pH, var. ionic strength;

DOI:10.1021/jm00385a023

Reference yield:

mesna (19767-45-4) + cis-4-hydroxycyclophosphamide (61903-29-5,88852-77-1,40277-05-2,61903-30-8,88852-78-2) → aldophosphamide (35144-64-0) + trans-4-hydroperoxycyclophosphamide (39800-16-3,56922-83-9,61903-31-9,62435-42-1,146566-40-7) + aldophosphamide hydrate (88685-78-3) + C9H21Cl2N2O6PS2 (105639-84-7) + cis-Mosfosfamide (84210-72-0,88859-04-5) + 2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ5-[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid (92745-18-1,88859-04-5)

Guidance literature:

With acetate buffer; In water; at 37 ℃;

DOI:10.1021/jm00385a023

upstream raw materials:

mesna

cis-4-hydroxycyclophosphamide

cis-Mosfosfamide

Refernces