Technology Process of (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane
There total 8 articles about (1R,2R)-2-(chloromethyl)-1-(dicyclohexylphosphinyl)cyclopentane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
p-toluenesulfonyl chloride;
In
pyridine;
for 30h;
Ambient temperature;
DOI:10.1248/cpb.40.2921
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4-dimethylaminopyrrolidine, triethylamine / tetrahydrofuran / 16 h / Ambient temperature
2: pyridine / 20 h / Ambient temperature
3: 1.) sodium / 1.) 1,4-dioxane, reflux, 5 h, 2.) THF, a) ice cooling, 2 h, b) RT, 16 h
4: 10percent aq. H2O2, HCl / methanol / 2 h
5: 76 percent / H2 / 5percent Raney nickel (W6) / ethanol / 120 h / 80 °C / 76000 Torr
6: 54 percent / tosyl chloride / pyridine / 30 h / Ambient temperature
With
pyridine; hydrogenchloride; hydrogen; dihydrogen peroxide; sodium; dimethyl-pyrrolidin-3-yl-amine; triethylamine; p-toluenesulfonyl chloride;
Raney nickel (W6);
In
tetrahydrofuran; pyridine; methanol; ethanol;
DOI:10.1248/cpb.40.2921
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
2: 4-dimethylaminopyrrolidine, triethylamine / tetrahydrofuran / 16 h / Ambient temperature
3: pyridine / 20 h / Ambient temperature
4: 1.) sodium / 1.) 1,4-dioxane, reflux, 5 h, 2.) THF, a) ice cooling, 2 h, b) RT, 16 h
5: 10percent aq. H2O2, HCl / methanol / 2 h
6: 76 percent / H2 / 5percent Raney nickel (W6) / ethanol / 120 h / 80 °C / 76000 Torr
7: 54 percent / tosyl chloride / pyridine / 30 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; dihydrogen peroxide; sodium; dimethyl-pyrrolidin-3-yl-amine; triethylamine; p-toluenesulfonyl chloride;
Raney nickel (W6);
In
tetrahydrofuran; pyridine; methanol; ethanol;
DOI:10.1248/cpb.40.2921
