(2R,3R)-2-Methyl-3-phenethyl-oxirane

Base Information

• Chemical Name: (2R,3R)-2-Methyl-3-phenethyl-oxirane
• CAS No.: 86088-37-1
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 86088-37-1.mol

Synonyms:

Chemical Property of (2R,3R)-2-Methyl-3-phenethyl-oxirane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-2-Methyl-3-phenethyl-oxirane

There total 4 articles about (2R,3R)-2-Methyl-3-phenethyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → (2R,3R)-2-Methyl-3-phenethyl-oxirane (86088-37-1,86088-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: baker's yeast, D-glucose / aq. ethanol / 3 h / 20 - 30 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 3040 Torr / Ambient temperature

3: CH₂Cl₂; pyridine / 1.) 0 deg C, 2.) room temp.; overnight

4: sodium cyanoborohydride / hexamethylphosphoric acid triamide

With baker's yeast; D-glucose; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane;

DOI:10.1055/s-1980-28921

Reference yield:

(2S,3R,E)-5-phenylpent-4-ene-2,3-diol (67470-74-0) → (2R,3R)-2-Methyl-3-phenethyl-oxirane (86088-37-1,86088-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 3040 Torr / Ambient temperature

2: CH₂Cl₂; pyridine / 1.) 0 deg C, 2.) room temp.; overnight

3: sodium cyanoborohydride / hexamethylphosphoric acid triamide

With hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane;

DOI:10.1055/s-1980-28921

Reference yield:

(2S,3R)-5-Phenyl-2-tosyloxy-3-pentanol (73444-36-7) → (2R,3R)-2-Methyl-3-phenethyl-oxirane (86088-37-1,86088-38-2)

Guidance literature:

With sodium cyanoborohydride; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1055/s-1980-28921

upstream raw materials:

(2S,3R)-5-Phenyl-2-tosyloxy-3-pentanol

(E)-3-phenylpropenal

(2S,3R,E)-5-phenylpent-4-ene-2,3-diol

(2S,3R)-5-Phenylpentane-2,3-diol