3-(1-benzyl-3-indolyl)propanethiol

Base Information

• Chemical Name: 3-(1-benzyl-3-indolyl)propanethiol
• CAS No.: 128083-17-0
• Molecular Formula: C₁₈H₁₉NS
• Molecular Weight: 281.422
• Mol file: 128083-17-0.mol

Synonyms:

Chemical Property of 3-(1-benzyl-3-indolyl)propanethiol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(1-benzyl-3-indolyl)propanethiol

There total 2 articles about 3-(1-benzyl-3-indolyl)propanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-(2-tetrahydrothiopyranylthio)-3-(1-benzyl-3-indolyl)propane (128083-15-8) → 3-(1-benzyl-3-indolyl)propanethiol (128083-17-0)

Guidance literature:

With hydrogenchloride; N-benzyl-N-phenylhydrazine hydrochloride; acetic acid; for 8h; Heating; also with BF₃*OEt₂, ethanethiol;

DOI:10.1007/BF00470691

Reference yield:

3,4-dihydro-2H-thiopyran (13042-80-3) + N-benzyl-N-phenylhydrazine hydrochloride (5705-15-7) → 3-(1-benzyl-3-indolyl)propanethiol (128083-17-0)

Guidance literature:

With hydrogenchloride; water; acetic acid; Yield given. Multistep reaction; 1) dioxane, 4h, reflux, 2) 11h, reflux;

DOI:10.1007/BF00470691

upstream raw materials:

3,4-dihydro-2H-thiopyran

N-benzyl-N-phenylhydrazine hydrochloride

1-(2-tetrahydrothiopyranylthio)-3-(1-benzyl-3-indolyl)propane

Refernces