Technology Process of C19H16F3N5
There total 16 articles about C19H16F3N5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 2h;
DOI:10.1016/j.bmcl.2014.05.082
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h / 20 °C
2: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C
With
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.05.082
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C
2: diphenyl phosphoryl azide; triphenylphosphine; di-isopropyl azodicarboxylate / 16 h / 0 - 20 °C
3: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h / 20 °C
4: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C
With
di-isopropyl azodicarboxylate; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.05.082
