(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester
CAS No.:247147-01-9
Molecular Formula:C₃₉H₅₁N₂O₉P
Molecular Weight:722.816
Hs Code.:

(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

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Chemical Property of (S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

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Technology Process of (S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

There total 3 articles about (S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 247147-01-9
(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 20 °C

2: NaOH / ethanol / 20 °C

3: 47 percent / DIEA; HOBt; EDCI / CH₂Cl₂; tetrahydrofuran / 0.5 h / 20 °C

4: NaI; (n-Bu)4NHSO₄; Et₃N / CHCl₃ / Heating

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0102248

Reference yield:

: 13398-05-5
acetic acid-(α-chloro-isobutyl ester)

: 247146-97-0
(S)-2-{(S)-2-Biphenyl-4-ylmethyl-3-[((R)-1-tert-butoxycarbonylamino-ethyl)-hydroxy-phosphinoyl]-propionylamino}-propionic acid benzyl ester

: 247147-01-9
(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; triethylamine; sodium iodide; In chloroform; Heating;
DOI:10.1021/jm0102248

Reference yield:

: 374075-32-8
(S)-2-Biphenyl-4-ylmethyl-3-[((R)-1-tert-butoxycarbonylamino-ethyl)-hydroxy-phosphinoyl]-propionic acid

: 247147-01-9
(S)-2-{(S)-3-[(1-Acetoxy-2-methyl-propoxy)-((R)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / DIEA; HOBt; EDCI / CH₂Cl₂; tetrahydrofuran / 0.5 h / 20 °C

2: NaI; (n-Bu)4NHSO₄; Et₃N / CHCl₃ / Heating

With tetra(n-butyl)ammonium hydrogensulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm0102248