Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Base Information

Chemical Name:Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester
CAS No.:1054682-46-0
Molecular Formula:C₄₅H₄₈N₅O₉PSi
Molecular Weight:861.963
Hs Code.:

Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

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Chemical Property of Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

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Technology Process of Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

There total 4 articles about Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890-38-0
2-deoxyinosine

: 1054682-46-0
Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Py

2: iPr₂EtN / CH₂Cl₂ / 1.5 h

3: 1H-tetrazole / acetonitrile

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1054682-46-0
Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Py

2: iPr₂EtN / CH₂Cl₂ / 1.5 h

3: 1H-tetrazole / acetonitrile

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c

Reference yield:

: 175354-96-8
5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine

: 1054682-46-0
Phosphorous acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: iPr₂EtN / CH₂Cl₂ / 1.5 h

2: 1H-tetrazole / acetonitrile

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c