4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-⁽¹⁸⁾F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide

Base Information

• Chemical Name: 4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-⁽¹⁸⁾F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide
• CAS No.: 1186029-54-8
• Molecular Formula: C₃₀H₃₇Cl₂F₂N₅O₇
• Molecular Weight: 687.557

Synonyms:

Chemical Property of 4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-⁽¹⁸⁾F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide

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Technology Process of 4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-⁽¹⁸⁾F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide

There total 1 articles about 4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-⁽¹⁸⁾F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid 2-[2-(2-2-[6-4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoylamino-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-51-5) → 4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-(18)F-fluoro-ethoxy)-ethoxy]-ethoxyethoxy)-quinazolin-6-yl]-amide (1186029-54-8)

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; In dimethyl sulfoxide; at 120 ℃; for 0.333333h; Autoclave;

DOI:10.1002/jlcr.1569

upstream raw materials:

methanesulfonic acid 2-[2-(2-2-[6-4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoylamino-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester

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