7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid

Base Information

• Chemical Name: 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid
• CAS No.: 114651-99-9
• Molecular Formula: C₂₃H₂₆O₅
• Molecular Weight: 382.456
• Mol file: 114651-99-9.mol

Synonyms:

Chemical Property of 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid

There total 3 articles about 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid (114651-99-9,114652-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA, TMEDA / tetrahydrofuran; hexane / 1.2 h / 0 °C

2: tetrahydrofuran / 15 h / 0 °C

With N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/jo00249a036

Reference yield:

(E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-acrylic acid methyl ester (87101-68-6) → 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid (114651-99-9,114652-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / i-Bu₂AlH / toluene / 0.5 h / 0 °C

2: MnO₂ / benzene; CHCl₃ / 35 h / Ambient temperature

3: tetrahydrofuran / 15 h / 0 °C

With manganese(IV) oxide; diisobutylaluminium hydride; In tetrahydrofuran; chloroform; toluene; benzene;

DOI:10.1021/jo00249a036

Reference yield:

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-(E)-propenol (114651-97-7) → 7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienoic acid (114651-99-9,114652-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: MnO₂ / benzene; CHCl₃ / 35 h / Ambient temperature

2: tetrahydrofuran / 15 h / 0 °C

With manganese(IV) oxide; In tetrahydrofuran; chloroform; benzene;

DOI:10.1021/jo00249a036

upstream raw materials:

(4-carboxybutyl)triphenylphosphonium bromide

(E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-acrylic acid methyl ester

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-(E)-propenol

Downstream raw materials:

7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienamide

7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienylamine

isojulandine

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1,6,7,8,9,9a-hexahydro-4H-quinolizin-4-one