(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

Base Information

Chemical Name:(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester
CAS No.:107668-26-8
Molecular Formula:C₂₇H₂₈N₂O₇S
Molecular Weight:524.595
Hs Code.:

(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

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Chemical Property of (R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

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Technology Process of (R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

There total 5 articles about (R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107645-26-1
(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester

: 107668-26-8
(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

Guidance literature:: With hydrogen; platinum; Yield given;
DOI:10.1016/S0040-4039(00)84753-X

Reference yield:

: 59034-26-3
(2S,5R,6R)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 107668-26-8
(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DBU

2: m-chloroperoxybenzoic acid

3: methyl acrylate / Heating

4: phosphorus tribromide

5: H₂ / Pt

With hydrogen; phosphorus tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; acrylic acid methyl ester; 3-chloro-benzenecarboperoxoic acid; platinum;
DOI:10.1016/S0040-4039(00)84753-X

Reference yield:

: 66363-43-7
(2S,5R,6S)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 107668-26-8
(R)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methoxycarbonyl-ethylsulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: m-chloroperoxybenzoic acid

2: methyl acrylate / Heating

3: phosphorus tribromide

4: H₂ / Pt

With hydrogen; phosphorus tribromide; acrylic acid methyl ester; 3-chloro-benzenecarboperoxoic acid; platinum;
DOI:10.1016/S0040-4039(00)84753-X