1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Base Information

Chemical Name:1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one
CAS No.:99809-45-7
Molecular Formula:C₁₆H₂₈O₄
Molecular Weight:284.396
Hs Code.:

Synonyms:

Suppliers and Price of 1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

There total 10 articles about 1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004-36-0
2,6-dimethylpyrone

: 99809-45-7
1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: 58 percent / N-bromosuccinimide, benzoyl peroxide / benzene / 4.5 h / Heating

2: 100 percent / ethanol / 1 h / Heating

3: 1.) NaH / 1) THF, room temp. 1h, 2) reflux, 1h

4: 100 percent / p-toluenesulfonic acid / benzene / Heating

5: 58 percent / aluminum amalgam / tetrahydrofuran; H₂O / 4 h / 0 °C

6: acetone / 2 h / Heating

7: ethyl acetate / 1 h / Heating

8: K₂CO₃, H₂₀ / methanol / 0.5 h / 0 °C

9: 2.) 20percent aq. TiCl₃ / Raney Ni W-2 / 1) ethanol, reflux, 3 h 2) acetone, RT, 1 h

With N-Bromosuccinimide; Perbenzoic acid; titanium(III) chloride; aluminium amalgam; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; Raney Ni W-2; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; acetone; benzene;
DOI:10.1021/jo00353a014

Reference yield:

: 99809-37-7
2-(bromomethyl)-6-methyl-4H-pyran-4-one

: 99809-45-7
1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / ethanol / 1 h / Heating

2: 1.) NaH / 1) THF, room temp. 1h, 2) reflux, 1h

3: 100 percent / p-toluenesulfonic acid / benzene / Heating

4: 58 percent / aluminum amalgam / tetrahydrofuran; H₂O / 4 h / 0 °C

5: acetone / 2 h / Heating

6: ethyl acetate / 1 h / Heating

7: K₂CO₃, H₂₀ / methanol / 0.5 h / 0 °C

8: 2.) 20percent aq. TiCl₃ / Raney Ni W-2 / 1) ethanol, reflux, 3 h 2) acetone, RT, 1 h

With titanium(III) chloride; aluminium amalgam; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; Raney Ni W-2; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; acetone; benzene;
DOI:10.1021/jo00353a014

Reference yield:

: 99809-43-5
2-<2-<2,2-(ethylenedioxy)cyclohexyl>etyl>-6-methyl-4H-pyran-4-one

: 99809-45-7
1-(1,4-Dioxa-spiro[4.5]dec-6-yl)-7-hydroxy-octan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 2 h / Heating

2: ethyl acetate / 1 h / Heating

3: K₂CO₃, H₂₀ / methanol / 0.5 h / 0 °C

4: 2.) 20percent aq. TiCl₃ / Raney Ni W-2 / 1) ethanol, reflux, 3 h 2) acetone, RT, 1 h

With titanium(III) chloride; water; potassium carbonate; Raney Ni W-2; In methanol; ethyl acetate; acetone;
DOI:10.1021/jo00353a014