C₅₀H₆₃ClO₇Si₂

Base Information

Chemical Name:C₅₀H₆₃ClO₇Si₂
CAS No.:516457-70-8
Molecular Formula:C₅₀H₆₃ClO₇Si₂
Molecular Weight:867.67
Hs Code.:

C<sub>50</sub>H<sub>63</sub>ClO<sub>7</sub>Si<sub>2</sub>

Synonyms:

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Chemical Property of C₅₀H₆₃ClO₇Si₂

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Technology Process of C₅₀H₆₃ClO₇Si₂

There total 21 articles about C₅₀H₆₃ClO₇Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4S,5S)-5-(4-Methoxy-benzyloxymethyl)-tetrahydro-furan-2,4-diol

: 516457-70-8
C₅₀H₆₃ClO₇Si₂

Guidance literature:: Multi-step reaction with 19 steps

1: acetonitrile

2: NaOMe / methanol

3: 42 percent / imidazole

4: 100 percent / LiAlH₄ / tetrahydrofuran

5: pyridine

6: LiBr / dimethylformamide

7: 68 percent / s-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide

8: 45 percent / H₂O; N-chlorosuccinimide / dimethylformamide / 6 h / 50 °C

9: 80 percent / AcOH / tetrahydrofuran; H₂O

10: Dess-Martin periodinane / CH₂Cl₂

11: KHMDS; 18-crown-6 / tetrahydrofuran; toluene

12: 100 percent / DIBAL / toluene

13: Dess-Martin periodinane / CH₂Cl₂

14: t-BuMgCl / tetrahydrofuran

15: 86 percent / Al-Hg / tetrahydrofuran; H₂O

16: 99 percent / pyridine

17: 93 percent / HF / pyridine; tetrahydrofuran

18: 90 percent / TMSOTf; 2,6-lutidine / CH₂Cl₂

19: DMAP; Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; aluminium amalgam; hydrogen fluoride; tert-butylmagnesium chloride; water; sec.-butyllithium; sodium methylate; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; triethylamine; lithium bromide; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Wittig reaction / 10: Dess-Martin oxidation / 11: Still-modified Horner-Emmons reaction / 13: Dess-Martin oxidation;
DOI:10.1021/ol0341804

Reference yield:

: 516457-43-5
(2S,3S)-5-Methoxy-2-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-3-ol

: 516457-70-8
C₅₀H₆₃ClO₇Si₂

Guidance literature:: Multi-step reaction with 20 steps

1: 99 percent / 1 M HCl / H₂O; tetrahydrofuran

2: acetonitrile

3: NaOMe / methanol

4: 42 percent / imidazole

5: 100 percent / LiAlH₄ / tetrahydrofuran

6: pyridine

7: LiBr / dimethylformamide

8: 68 percent / s-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide

9: 45 percent / H₂O; N-chlorosuccinimide / dimethylformamide / 6 h / 50 °C

10: 80 percent / AcOH / tetrahydrofuran; H₂O

11: Dess-Martin periodinane / CH₂Cl₂

12: KHMDS; 18-crown-6 / tetrahydrofuran; toluene

13: 100 percent / DIBAL / toluene

14: Dess-Martin periodinane / CH₂Cl₂

15: t-BuMgCl / tetrahydrofuran

16: 86 percent / Al-Hg / tetrahydrofuran; H₂O

17: 99 percent / pyridine

18: 93 percent / HF / pyridine; tetrahydrofuran

19: 90 percent / TMSOTf; 2,6-lutidine / CH₂Cl₂

20: DMAP; Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; dmap; N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; aluminium amalgam; hydrogen fluoride; tert-butylmagnesium chloride; water; sec.-butyllithium; sodium methylate; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; triethylamine; lithium bromide; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: Wittig reaction / 11: Dess-Martin oxidation / 12: Still-modified Horner-Emmons reaction / 14: Dess-Martin oxidation;
DOI:10.1021/ol0341804

Reference yield:

: [(4S,5S)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-acetic acid methyl ester

: 516457-70-8
C₅₀H₆₃ClO₇Si₂

Guidance literature:: Multi-step reaction with 17 steps

1: 42 percent / imidazole

2: 100 percent / LiAlH₄ / tetrahydrofuran

3: pyridine

4: LiBr / dimethylformamide

5: 68 percent / s-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide

6: 45 percent / H₂O; N-chlorosuccinimide / dimethylformamide / 6 h / 50 °C

7: 80 percent / AcOH / tetrahydrofuran; H₂O

8: Dess-Martin periodinane / CH₂Cl₂

9: KHMDS; 18-crown-6 / tetrahydrofuran; toluene

10: 100 percent / DIBAL / toluene

11: Dess-Martin periodinane / CH₂Cl₂

12: t-BuMgCl / tetrahydrofuran

13: 86 percent / Al-Hg / tetrahydrofuran; H₂O

14: 99 percent / pyridine

15: 93 percent / HF / pyridine; tetrahydrofuran

16: 90 percent / TMSOTf; 2,6-lutidine / CH₂Cl₂

17: DMAP; Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; aluminium amalgam; hydrogen fluoride; tert-butylmagnesium chloride; water; sec.-butyllithium; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; triethylamine; lithium bromide; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 8: Dess-Martin oxidation / 9: Still-modified Horner-Emmons reaction / 11: Dess-Martin oxidation;
DOI:10.1021/ol0341804