dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

Base Information

Chemical Name:dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine
CAS No.:868074-73-1
Molecular Formula:C₅₆H₉₇N₄O₁₂PSi₄
Molecular Weight:1161.72
Hs Code.:

dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

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Chemical Property of dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

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Technology Process of dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

There total 4 articles about dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 868074-71-9
8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-5-(5'-iodopentyl)-2,4-dimethoxy-6,7-dioxopteridine

: 50651-75-7
silver dibenzylphosphate

: 868074-73-1
dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

Guidance literature:: In acetonitrile; for 10h; Heating;
DOI:10.1021/jo051332v

Reference yield:

: 669088-29-3
2,6-dimethoxy-5-nitro-N-((2S,3S,4R)-2,3,4,5-tetrakis(tert-butyldimethylsilyloxy)pentyl)pyrimidine-4-amine

: 868074-73-1
dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / methanol / 72 h / 20 °C / 760 Torr

2.1: Et₃N / CH₂Cl₂ / 20 °C

2.2: 1.55 g / Et₃N / ethanol / 72 h / Heating

3.1: 68 percent / K₂CO₃ / acetonitrile / Heating

4.1: 71 percent / acetonitrile / 10 h / Heating

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo051332v

Reference yield:

: 868074-69-5
8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopteridine

: 868074-73-1
dibenzyl 4-[8-(2',3',4',5'-tetrakis-(tert-butyldimethylsilyl)-D-ribityl)-5,6,7,8-tetrahydro-2,4-dimethoxy-6,7-dioxopterid-5-yl]pentane 1-phosphateine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / K₂CO₃ / acetonitrile / Heating

2: 71 percent / acetonitrile / 10 h / Heating

With potassium carbonate; In acetonitrile;
DOI:10.1021/jo051332v