5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Base Information

Chemical Name:5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole
CAS No.:59179-94-1
Molecular Formula:C₃₇H₃₁Cl₂N₃O
Molecular Weight:604.579
Hs Code.:

5-chloro-3-(o-chlorophenyl)-1-methyl-2-<<N<sup>α</sup>-(tritylglycyl)amino>methyl>indole

Synonyms:

Suppliers and Price of 5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

There total 5 articles about 5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24107-07-1
ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

: 59179-94-1
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; triethylamine; In diethyl ether; ethanol;
DOI:10.1021/jm00181a013

Reference yield:

: 74098-80-9
5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylic acid

: 59179-94-1
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

2: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

3: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; thionyl chloride; ammonia; triethylamine; In diethyl ether;
DOI:10.1021/jm00181a013

Reference yield:

: 74088-62-3
5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxamide

: 59179-94-1
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-(tritylglycyl)amino>methyl>indole

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

2: 1.) SOCl₂, HMPA, 2.) Et₃N / 1.) -5 deg C, 10 min, 2.) Et₂O, RT, overnight

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; thionyl chloride; triethylamine; In diethyl ether;
DOI:10.1021/jm00181a013