(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Base Information

Chemical Name:(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide
CAS No.:71890-54-5
Molecular Formula:C₃₉H₅₀N₆O₆S
Molecular Weight:730.929
Hs Code.:

(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

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Chemical Property of (S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

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Technology Process of (S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

There total 9 articles about (S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24003-17-6
phenyl-acetic acid pentachlorophenyl ester

: 51165-05-0,78081-73-9
H-Phe-Phe-Gly-Leu-Met-NH₂

: 71890-54-5
(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Guidance literature:: DOI:10.1016/0223-5234(88)90006-2

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 71890-54-5
(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C

2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT

3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C

4: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

5: 90 percent

With 4-methyl-morpholine; sodium hydroxide; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(88)90006-2

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 71890-54-5
(S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 93.6 percent / NMM, IBCF / dimethylformamide / -20 °C

2: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C

4: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

5: 90 percent

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(88)90006-2