1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol

Base Information

• Chemical Name: 1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol
• CAS No.: 147127-66-0
• Molecular Formula: C₄₅H₅₁N₆O₁₅P₃
• Molecular Weight: 1008.85
• Mol file: 147127-66-0.mol

Synonyms:

Chemical Property of 1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol

There total 18 articles about 1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester (109522-11-4,145842-33-7) → Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester (109522-12-5,112294-74-3,141040-51-9,145842-34-8,145842-35-9,147127-66-0)

Guidance literature:

With tert.-butylhydroperoxide;

DOI:10.1016/S0040-4039(00)96110-0

Reference yield: 67.0%

Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2R,3S,4R,5R,6R)-2,3,6-tris-benzyloxy-4,5-bis-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester → Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester (109522-12-5,112294-74-3,141040-51-9,145842-34-8,145842-35-9,147127-66-0)

Guidance literature:

DOI:10.1016/0008-6215(92)85046-3

Reference yield:

bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) → 1L-(-)-2,3,5-tri-O-benzyl-1,4,6-tris-chiro-inositol (147127-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / CH₂Cl₂ / 1 h / Ambient temperature

2: 60percent aq. t-BuOOH

With 1H-tetrazole; tert.-butylhydroperoxide; In dichloromethane;

DOI:10.1021/jm00033a007

upstream raw materials:

Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2R,3S,4R,5R,6S)-2,3,6-tris-benzyloxy-4,5-bis-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester

(±)-2,3,6-tri-O-benzyl-myo-inositol

bis(2-cyanoethyl) diisopropylamidophosphite

(±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol