(+/-)-(4-methylcyclohexylidene)fluoroethanol

Base Information

• Chemical Name: (+/-)-(4-methylcyclohexylidene)fluoroethanol
• CAS No.: 114837-05-7
• Molecular Formula: C₉H₁₅FO
• Molecular Weight: 158.216
• Mol file: 114837-05-7.mol

Synonyms:

Chemical Property of (+/-)-(4-methylcyclohexylidene)fluoroethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(4-methylcyclohexylidene)fluoroethanol

There total 4 articles about (+/-)-(4-methylcyclohexylidene)fluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl-(+/-)-(4-methylcyclohexylidene)fluoroacetate (114837-04-6,114924-01-5) → (+/-)-(4-methylcyclohexylidene)fluoroethanol (114837-05-7,114924-02-6)

Guidance literature:

With aluminium trichloride; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1021/ja00222a017

Reference yield:

1-methylcyclohexan-4-one (589-92-4) → (+/-)-(4-methylcyclohexylidene)fluoroethanol (114837-05-7,114924-02-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 17.5 percent / n-butyllithium / tetrahydrofuran; diethyl ether; pentane; hexane / 0.5 h / -130 - -110 °C

2: 68 percent / concentrated sulfuric acid / H₂O / 24 h / -10 °C

3: 98.8 percent / diethyl ether / 0 °C

4: 84 percent / LiAlH, AlCl₃ / diethyl ether / 2 h / 0 °C

With n-butyllithium; aluminium trichloride; sulfuric acid; In tetrahydrofuran; diethyl ether; hexane; water; pentane;

DOI:10.1021/ja00222a017

Reference yield:

(trifluoroethylene)-4-methylcyclohexanol → (+/-)-(4-methylcyclohexylidene)fluoroethanol (114837-05-7,114924-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / concentrated sulfuric acid / H₂O / 24 h / -10 °C

2: 98.8 percent / diethyl ether / 0 °C

3: 84 percent / LiAlH, AlCl₃ / diethyl ether / 2 h / 0 °C

With aluminium trichloride; sulfuric acid; In diethyl ether; water;

DOI:10.1021/ja00222a017

upstream raw materials:

methyl-(+/-)-(4-methylcyclohexylidene)fluoroacetate

1-methylcyclohexan-4-one

(+/-)-(4-methylcyclohexylidene)fluoroacetic acid

Downstream raw materials:

(+/-)-(4-methylcyclohexylidene)-1-fluoro-2-chloroethane