2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate

Base Information

• Chemical Name: 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate
• CAS No.: 146331-54-6
• Molecular Formula: C₆H₁₅N*C₃₄H₃₆ClN₆O₇P
• Molecular Weight: 808.314
• Mol file: 146331-54-6.mol

Synonyms:

Chemical Property of 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate

There total 4 articles about 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-2'-deoxyadenosine (4291-63-8) → 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate (146331-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / dimethylformamide / Ambient temperature

2: 61 percent / pyridine / Ambient temperature

3: 1) PCl₃, N-methylmorpholine, 1,2,4-triazole, 2) water / 1) CH₂Cl₂, r.t., 30 min

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; water; phosphorus trichloride; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19920750716

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate (146331-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / pyridine / Ambient temperature

2: 1) PCl₃, N-methylmorpholine, 1,2,4-triazole, 2) water / 1) CH₂Cl₂, r.t., 30 min

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; water; phosphorus trichloride;

DOI:10.1002/hlca.19920750716

Reference yield:

2-chloro-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-<<(dimethylamino)methylidene>amino>-9H-purine (146196-18-1) → 2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine 3'-triethylammonium phosphonate (146331-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / pyridine / Ambient temperature

2: 1) PCl₃, N-methylmorpholine, 1,2,4-triazole, 2) water / 1) CH₂Cl₂, r.t., 30 min

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; water; phosphorus trichloride;

DOI:10.1002/hlca.19920750716

upstream raw materials:

triethylamine carbonate

2-chloro-9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<<(dimethylamino)methylidene>amino>-9H-purine

4,4'-dimethoxytrityl chloride

2-chloro-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-<<(dimethylamino)methylidene>amino>-9H-purine