Technology Process of 3-Hydroxymethyl-4,6-dimethoxy-2,5-dimethyl-benzoic acid methyl ester
There total 2 articles about 3-Hydroxymethyl-4,6-dimethoxy-2,5-dimethyl-benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
isopropyl alcohol;
DOI:10.1021/jm960437a
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 6.8 g / K2CO3 / acetone / 2 h / Heating
2: 3.18 g / NaBH4 / propan-2-ol
With
sodium tetrahydroborate; potassium carbonate;
In
isopropyl alcohol; acetone;
DOI:10.1021/jm960437a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 3.35 g / pyridine, (dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 100 percent / BF3*OEt2 / toluene / 0.25 h / Ambient temperature
3: 2.97 g / K2CO3 / acetone / Heating
4: 95 percent / aq. KOH / dimethylsulfoxide
5: oxalyl chloride / CH2Cl2 / a) RT, 30 min, b) reflux, 30 min
6: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C, 10 min to RT, overnight
With
pyridine; dmap; potassium hydroxide; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm960437a
