[(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester

Base Information

• Chemical Name: [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester
• CAS No.: 219555-92-7
• Molecular Formula: C₃₂H₄₃N₃O₁₂
• Molecular Weight: 661.706
• Mol file: 219555-92-7.mol

Synonyms:

Chemical Property of [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester

There total 8 articles about [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-2-nitrophenol (119-34-6) → [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester (219555-92-7)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂O / 2 h / 50 °C

2: K₂CO₃ / dimethylformamide / 4 h / 120 °C

3: 3M HCl / ethanol / Heating

4: Et₃N / CH₂Cl₂

5: cyclohexene / 10percent Pd/C / ethanol / Heating

6: 1,8-bis(dimethylamino)naphthalene / acetonitrile / Heating

With hydrogenchloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; triethylamine; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)02008-5

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester (219555-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: cyclohexene / 10percent Pd/C / ethanol / Heating

3: 1,8-bis(dimethylamino)naphthalene / acetonitrile / Heating

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(98)02008-5

Reference yield:

N-(4-hydroxy-3-nitrophenyl)acetamide (51288-37-0) → [(2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-5-tert-butoxycarbonylamino-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester (219555-92-7)

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 4 h / 120 °C

2: 3M HCl / ethanol / Heating

3: Et₃N / CH₂Cl₂

4: cyclohexene / 10percent Pd/C / ethanol / Heating

5: 1,8-bis(dimethylamino)naphthalene / acetonitrile / Heating

With hydrogenchloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; triethylamine; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)02008-5

upstream raw materials:

bromoacetic acid methyl ester

{3-Amino-4-[2-(2-amino-5-methyl-phenoxy)-ethoxy]-phenyl}-carbamic acid tert-butyl ester

4-amino-2-nitrophenol

di-tert-butyl dicarbonate

Downstream raw materials:

[(5-Amino-2-{2-[2-(bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-methoxycarbonylmethyl-amino]-acetic acid methyl ester