(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

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Chemical Name:(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide
CAS No.:1351167-67-3
Molecular Formula:C₂₄H₂₉ClFN₅O₄S
Molecular Weight:538.043
Hs Code.:

Synonyms:

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Chemical Property of (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

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Technology Process of (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

There total 8 articles about (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 1351167-67-3
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 4 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium carbonate / dimethyl sulfoxide / 48 h / 120 °C

6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / 2068.65 Torr

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.2: pH 1

9.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

10.1: N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1351168-76-7
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinic acid

: 1351167-67-3
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2: N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 4 h / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1351168-75-6
(S)-methyl 5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinate

: 1351167-67-3
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

1.2: pH 1

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

3.1: N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 4 h / 20 °C

With thionyl chloride; water; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;