LY-3177833

Base Information

Chemical Name:LY-3177833
CAS No.:1627696-51-8
Molecular Formula:C₁₆H₁₂FN₅O
Molecular Weight:309.303
Hs Code.:
Mol file:1627696-51-8.mol

Synonyms:

Suppliers and Price of LY-3177833

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
LY3177833 >98%
250 mg
$ 1300.00

Crysdot
LY-3177833 98+%
50mg
$ 277.00

Crysdot
LY-3177833 98+%
10mg
$ 97.00

Crysdot
LY-3177833 98+%
5mg
$ 55.00

ChemScene
LY3177833 99.78%
5mg
$ 120.00

Cayman Chemical
LY3177833 ≥98%
50mg
$ 600.00

Cayman Chemical
LY3177833 ≥98%
25mg
$ 319.00

Cayman Chemical
LY3177833 ≥98%
10mg
$ 135.00

Cayman Chemical
LY3177833 ≥98%
5mg
$ 75.00

AK Scientific
CID81689696
50mg
$ 910.00

Total 14 raw suppliers

Chemical Property of LY-3177833

Chemical Property:

Boiling Point:660.7±55.0 °C(Predicted)
PKA:11.67±0.40(Predicted)
Density:1.398±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

LY3177833 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.

Technology Process of LY-3177833

There total 22 articles about LY-3177833 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 552846-17-0
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate

: 6-bromo-3-(5-fluoropyrimidin-4-yl)-2-[(1R)-1-(4-methoxyphenyl)ethyl]-3-methyl-isoindolin-1-one

: 1627696-51-8
3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one

Guidance literature:: tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate; 6-bromo-3-(5-fluoropyrimidin-4-yl)-2-[(1R)-1-(4-methoxyphenyl)ethyl]-3-methyl-isoindolin-1-one; With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

With trifluoroacetic acid; at 70 - 80 ℃; for 22h;