3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

Base Information

• Chemical Name: 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate
• CAS No.: 864969-67-5
• Molecular Formula: C₂₅H₂₃F₂NO₇S
• Molecular Weight: 519.523
• Mol file: 864969-67-5.mol

Synonyms:

Chemical Property of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

There total 5 articles about 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylic acid (864969-66-4,864969-68-6) + chloromethyl isobutyrate (61644-18-6) → 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate (864969-67-5,864969-69-7)

Guidance literature:

4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloromethyl isobutyrate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1023/B:COHC.0000044578.17992.95

Reference yield:

2-[2-(difluoromethoxy)benzylidene]benzo[b]thiophen-3(2H)-one 1,1-dioxide → 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate (864969-67-5,864969-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 49 percent / acetic acid / ethanol / 3 h / Heating

2.1: 66 percent / KOH / ethanol / 3 h / 20 °C

3.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

3.2: 46 percent / dimethylformamide / 3 h / 20 °C

With potassium hydroxide; potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide; 1.1: Hantzsch cyclization;

DOI:10.1023/B:COHC.0000044578.17992.95

Reference yield:

3-(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate (864969-65-3) → 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate (864969-67-5,864969-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 66 percent / KOH / ethanol / 3 h / 20 °C

2.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

2.2: 46 percent / dimethylformamide / 3 h / 20 °C

With potassium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1023/B:COHC.0000044578.17992.95

upstream raw materials:

4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylic acid

chloromethyl isobutyrate

3-(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

o-difluoromethoxybenzaldehyde