cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

Base Information

Chemical Name:cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)
CAS No.:1365260-20-3
Molecular Formula:C₂₈H₃₄N₄O₅
Molecular Weight:506.602
Hs Code.:

Synonyms:

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Chemical Property of cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

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Technology Process of cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

There total 6 articles about cyclo(4(S)-NH-(Boc)Pro-Phe-Phe) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365260-19-0
N-Boc-Pro(4(S)-NH₂)-Phe-Phe-OH

: 1365260-20-3
cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm201402v

Reference yield:

: 1365260-17-8
N-Boc-Pro(4(S)-NH(Cbz))-Phe-Phe-OMe

: 1365260-20-3
cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 3 h / 0 - 20 °C / Inert atmosphere

1.2: pH 3 / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201402v

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1365260-20-3
cyclo(4(S)-NH-(Boc)Pro-Phe-Phe)

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane / water; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 3 h / 0 - 20 °C / Inert atmosphere

4.2: pH 3 / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201402v